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当前位置: 首页 > 产品中心 > peptide > ProteinTech/cyclind1单克隆抗体/150ul/60186-1-Ig
商品详细ProteinTech/cyclind1单克隆抗体/150ul/60186-1-Ig
ProteinTech/cyclind1单克隆抗体/150ul/60186-1-Ig
ProteinTech/cyclind1单克隆抗体/150ul/60186-1-Ig
商品编号: 60186-1-Ig
品牌: ptglab
市场价: ¥1980.00
美元价: 1188.00
产地: 美国(厂家直采)
公司:
产品分类: 多肽合成
公司分类: peptide
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Tested Applications

Positive WB detected inHeLa cells, SH-SY5Y cells,RAW 264.7 cells,MCF-7 cells,NIH/3T3 cells,A549 cells,A431 cells,HepG2 cells,SW 1990 cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:5000-1:20000
Sample-dependent, check data in validation data gallery

Published Applications

KD/KOSee 1 publications below
WBSee 327 publications below
IHCSee 9 publications below

Product Information

60186-1-Ig targets Cyclin D1 inWB, ELISA applications and shows reactivity with human,mouse samples.

Tested Reactivityhuman,mouse
Cited Reactivity cow, hamster, human, mouse, zebrafish
Host / IsotypeMouse / IgG2b
ClassMonoclonal
TypeAntibody
ImmunogenCyclin D1 fusion protein Ag0689
Full Namecyclin D1
Calculated molecular weight 295 aa, 34 kDa
Observed molecular weight 34 kDa
GenBank accession numberBC000076
Gene symbolCCND1
Gene ID (NCBI)595
ConjugateUnconjugated
FormLiquid
Purification MethodProtein A purification
Storage BufferPBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for-20oC storage.

Background Information

CCND1 (cyclin D1), also known as PRAD1 or BCL1, belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. CCND1 forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. The CCND1 gene, located on 11q13 has been reported to be overexpressed in mantle cell lymphoma (MCL) due to the chromosomal translocation. CCND1 has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Over-expression of CCND1 is known to correlate with the early onset of cancer and risk of tumor progression and metastasis.

Protocols

Product Specific Protocols
WB protocol for Cyclin D1 antibody 60186-1-IgDownload protocol
Standard Protocols
Click here to view our Standard Protocols
品牌介绍
Proteintech Group 由一群当时积极从事 NIH 资助研究的科学家于 2001 年创立。最初的创始人之一和现任首席执行官 Jason Li 博士在公司成立期间是伊利诺伊大学芝加哥分校的免疫学副教授。他谈到 Proteintech 成立背后的原因:“我们抱负的核心是一家由科学家组成的公司;一家为研究人员提供优势的抗体供应商,而不是投资者。”原创产品 – 原创产品Proteintech Group 的部分早期愿景是按照可能的最高标准生产自己的所有产品,并且从不从任何其他供应商处采购单一抗体。这将为研究人员提供许多优势,包括避免由不同公司以不同品牌出售相同抗体的方法——这是行业内出现的一种不受监管的做法1。Proteintech 以 100% 的原创产品为客户提供真诚和正直的品质,您将在本手册中不断发现这些品质。您只能直接从 Proteintech 或通过其批准的经销商之一购买 Proteintech 抗体 - 当您收到抗体并看到小瓶上的 Proteintech 标志时,请知道您拥有真正独一无二的东西。